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Hiroshi Tomoda Selected Research

1,11- O- o- methylbenzylidene- 7- O- p- cyanobenzoyl- 1,7,11- trideacetylpyripyropene A

11/2015PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.
11/2015New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

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Hiroshi Tomoda Research Topics

Disease

11Infections
01/2021 - 04/2010
8Neoplasms (Cancer)
01/2017 - 05/2004
7Atherosclerosis
11/2015 - 10/2004
4Hypercholesterolemia
11/2015 - 10/2004
3Tuberculosis (Tuberculoses)
01/2021 - 01/2016
3Myositis Ossificans (Fibrodysplasia Ossificans Progressiva)
01/2021 - 12/2008
3Obesity
08/2010 - 09/2007
2Inflammation (Inflammations)
01/2018 - 11/2015
2Diarrhea
01/2008 - 01/2004
2Colonic Neoplasms (Colon Cancer)
08/2007 - 05/2005
1Lymphoma (Lymphomas)
01/2019
1Dyslipidemias (Dyslipidemia)
01/2018
1Metabolic Diseases (Metabolic Disease)
01/2018
1Adenocarcinoma
12/2017
1Candidiasis (Moniliasis)
09/2016
1Mycoses (Diseases, Fungus)
09/2016
1Alzheimer Disease (Alzheimer's Disease)
12/2015
1Body Weight (Weight, Body)
11/2015
1Homozygous Familial Hypercholesterolemia
02/2015
1Non-alcoholic Fatty Liver Disease
02/2015
1Lipid Metabolism Disorders (Metabolism Disorders, Lipid)
02/2015
1Experimental Melanoma
04/2014
1Herpesviridae Infections (Herpesvirus Infection)
08/2013
1Cardiovascular Diseases (Cardiovascular Disease)
12/2011
1Virus Diseases (Viral Diseases)
09/2011
1Hyperlipidemias (Hyperlipidemia)
05/2011
1Gallstones (Gallstone)
06/2008
1Hemolysis
04/2008
1Atherosclerotic Plaque (Atheroma)
01/2008
1Lung Neoplasms (Lung Cancer)
05/2005
1Brain Neoplasms (Brain Tumor)
05/2005
1Breast Neoplasms (Breast Cancer)
05/2005
1Neoplasm Metastasis (Metastasis)
03/2005

Drug/Important Bio-Agent (IBA)

6Anti-Bacterial Agents (Antibiotics)IBA
01/2021 - 04/2010
5Therapeutic UsesIBA
01/2021 - 02/2015
5Pharmaceutical PreparationsIBA
01/2018 - 12/2015
4CholesterolIBA
11/2015 - 10/2004
4Sterol O-AcyltransferaseIBA
12/2011 - 09/2007
3pyripyropene AIBA
11/2015 - 05/2011
3Triglycerides (Triacylglycerol)IBA
08/2010 - 03/2005
3Indicators and Reagents (Reagents)IBA
08/2007 - 05/2004
2AcidsIBA
01/2019 - 01/2018
2Peptides (Polypeptides)IBA
05/2017 - 01/2016
2EnzymesIBA
01/2017 - 09/2007
2Messenger RNA (mRNA)IBA
11/2015 - 06/2008
2Proteins (Proteins, Gene)FDA Link
11/2015 - 06/2008
21,11- O- o- methylbenzylidene- 7- O- p- cyanobenzoyl- 1,7,11- trideacetylpyripyropene AIBA
11/2015 - 11/2015
2IsoenzymesIBA
02/2015 - 08/2010
2Cholesterol Esters (Cholesteryl Esters)IBA
10/2014 - 09/2007
2DNA (Deoxyribonucleic Acid)IBA
01/2012 - 05/2005
2oxidized low density lipoproteinIBA
05/2011 - 10/2007
2LDL Receptors (LDL Receptor)IBA
01/2008 - 01/2004
2ApolipoproteinsIBA
01/2008 - 01/2004
2Diacylglycerol O-AcyltransferaseIBA
09/2007 - 03/2005
2Bleomycin (Blenoxane)FDA LinkGeneric
08/2007 - 10/2004
1PyrazolesIBA
01/2021
1Activin Receptors (Activin Receptor)IBA
01/2021
1Ethambutol (Myambutol)FDA LinkGeneric
04/2019
1InflammasomesIBA
01/2018
1InterleukinsIBA
01/2018
1Fatty Acids (Saturated Fatty Acids)IBA
01/2018
1NucleotidesIBA
01/2018
1Leucine (L-Leucine)FDA Link
01/2018
1CytochalasinsIBA
12/2017
1biseokeaniamide BIBA
01/2017
1Ether (Diethyl Ether)IBA
09/2016
1Ketoconazole (Nizoral)FDA LinkGeneric
09/2016
1TrichothecenesIBA
02/2016
1Donepezil (Aricept)FDA LinkGeneric
12/2015
1Alanine Transaminase (SGPT)IBA
11/2015
1poststatinIBA
11/2015
1Sterol O-Acyltransferase 2IBA
11/2015
1lysocin EIBA
02/2015
1OxysterolsIBA
10/2014
1Melanins (Melanin)IBA
04/2014
1Melanocyte-Stimulating Hormones (MSH)IBA
04/2014
1Monophenol Monooxygenase (Tyrosinase)IBA
04/2014
1Acyclovir (Aciclovir)FDA LinkGeneric
08/2013
1Antiviral Agents (Antivirals)IBA
08/2013
1staphyloxanthinIBA
01/2012
1N-benzyl-N,1-dimethyl-2-propynylamineIBA
09/2011
1LuciferasesIBA
09/2011
1Acyl Coenzyme A (Acyl CoA)IBA
05/2011
1cholesteryl oleateIBA
05/2011
1Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA
03/2009
1cervinomycin A1IBA
02/2009
1XanthonesIBA
02/2009
1Type I Bone Morphogenetic Protein ReceptorsIBA
12/2008
1FluvastatinFDA Link
06/2008
1Atorvastatin (Lipitor)FDA Link
06/2008
1Lipoproteins (Lipoprotein)IBA
06/2008
1Type III Secretion SystemsIBA
04/2008
1malformin CIBA
08/2007
1triacsin CIBA
05/2005
1CaspasesIBA
05/2005
1Coenzyme A Ligases (Acid-Thiol Ligases)IBA
05/2005
1Cytochromes c (Cytochrome c)IBA
05/2005
1Apoptosomes (Apoptosome)IBA
05/2005

Therapy/Procedure

4Therapeutics
09/2016 - 09/2007
2Drug Therapy (Chemotherapy)
05/2005 - 03/2005